Will estriol oil help me sleep?

April 03, 2024

Will estriol oil help me sleep?


Estriol oil, a lesser-known member of the estrogen family, has been gaining attention for its potential impact on sleep quality. As part of hormone replacement therapy (HRT), estriol is often used to alleviate menopausal symptoms, including hot flashes, night sweats, and mood changes. But can it also help you get a better night’s sleep? Let’s explore the science behind estriol and its effect on sleep.

The Basics: What Is Estriol?

Estriol is a natural estrogen hormone produced by the body during pregnancy. It plays a crucial role in maintaining hormonal balance and supporting various bodily functions. While it’s less potent than other estrogens like estradiol, estriol still has essential roles in women’s health.

Estriol and Menopause

During menopause, estrogen levels decline significantly, leading to various symptoms. Estriol, as an estrogen replacement therapy, aims to address these symptoms. Here’s how it may impact sleep:

  1. Hot Flashes and Night Sweats: Estriol can help reduce the frequency and intensity of hot flashes and night sweats, allowing for more restful sleep.
  2. Mood Changes: Menopausal mood swings can disrupt sleep patterns. Estriol may help stabilize mood and promote better sleep.
  3. Vaginal Dryness: Estriol can relieve vaginal atrophy and dryness, which can affect sleep comfort.
  4. Urinary Tract Infections (UTIs): Estriol may lower the risk of UTIs, indirectly contributing to overall well-being and sleep quality.

The Science Behind Estriol and Sleep

  1. Neurotransmitters: Estriol interacts with neurotransmitters in the brain. It promotes serotonin production, which induces calmness and supports sleep. Additionally, it may enhance endorphin release, leading to feelings of euphoria and sedation.
  2. REM Sleep: Estriol may improve the quality of rapid eye movement (REM) sleep, the stage associated with dreaming and cognitive functioning. Better REM sleep contributes to overall sleep satisfaction.
  3. Circadian Rhythms: Estriol’s influence on circadian rhythms helps regulate sleep-wake cycles. A balanced circadian rhythm promotes better sleep.

Practical Considerations

  1. Consult Healthcare Professionals: Always consult your healthcare provider before using estriol oil or any HRT. Individual needs and risks vary, and personalized guidance is essential.
  2. Lab Testing: Regular lab testing helps measure estriol levels and ensures optimal dosing.
  3. Bioidentical Hormones: Estriol is a bioidentical hormone, meaning it closely resembles the body’s natural hormones. Bioidentical hormones are preferred by some due to their similarity to endogenous hormones.
  4. Risk Factors: While estriol is generally safe, it’s essential to consider individual factors.


Estriol oil may improve sleep quality for menopausal women experiencing symptoms. However, it’s crucial to weigh the benefits against potential risks and consult with a healthcare professional. Remember that information provided here is for informational purposes only, and personalized advice is essential for your specific situation.

Sweet dreams! 🌙💤