Does 7-keto DHEA help adrenal fatigue?

March 01, 2021

Does 7-keto DHEA help adrenal fatigue?

Does 7-keto DHEA help adrenal fatigue?

Are you feeling run down? No matter what, you can’t seem to feel energized or lose weight. Despite your best efforts, you’re fatigued and lack the energy to tackle daily tasks. 

Well, you may have adrenal fatigue and need 7-keto déhydroépiandrostérone or DHEA. It’s a DHEA supplement used to improve energy levels, provide fat-burning agents, and help adrenal fatigue and inefficiency. 

What is adrenal fatigue?

Adrenal fatigue is when your adrenal glands become tired or depleted from being bombarded with stress. Adrenal glands, located above both kidneys, are triangular-shaped glands, sometimes called suprarenal glands. The small glands help regulate your immune system, respond to stress, metabolism, blood pressure, and other crucial functions. 

Adrenal glands produce cortisol in response to stressful situations. For example, having a stressful job or going through a traumatic event. Stress occurs for various reasons and can build up over time. 

The adrenal glands produce cortisol, the stress hormone to help you combat feeling overwhelmed. But if you’re overwhelmed continuously, your adrenals grow weak from producing constant cortisol. The result is experiencing one or more of the following symptoms:

  • Extreme fatigue
  • Insomnia
  • Sugar and caffeine cravings
  • Moodiness and depression
  • Weight gain
  • Brain fog
  • Low sex drive

Adrenal fatigue symptoms can also be associated with other health conditions. It’s essential to speak to your healthcare provider if you believe you have adrenal fatigue and considering taking dehydroepiandrosterone or DHEA. 


Adrenal Fatigue vs. Adrenal Insufficiency

It’s important to note that there is insufficient evidence to support adrenal fatigue as a real medical diagnosis based on research. In the scientific community, not enough studies validate the health condition as a real issue. However, the alternative medical community has long treated adrenal fatigue and validates it as a real medical condition. 

On the other hand, adrenal insufficiency is supported in the medical community and seen as a medical condition. Adrenal insufficiency is an issue with the adrenal glands or pituitary gland in the brain that helps the body generate cortisol. The symptoms between adrenal fatigue and insufficiency are similar.

What is 7-Keto DHEA?

7-keto DHEA is made from the parent hormone DHEA in the adrenal glands. DHEA is one of the highest steroid hormones in the body and responsible for making other sex hormones. 7-keto DHEA is thought to have thermogenic qualities, which help your body eliminate calories to generate heat. 

The fat-burning ability of 7-keto DHEA is thought to increase resting metabolic rate (RMR). RMR is the amount of time it takes you to burn calories compared to other people in the same age group. If you have an increased metabolic rate, you can eat more calories and may be fitter. 

Due to its metabolism-boosting properties, some studies show that 7-keto encouraged fat burn in overweight adults and helped them lose more weight than those in the study who didn’t take the supplement. 


Difference between DHEA & 7-keto DHEA

One significant difference between dehydroepiandrosterone and 7-keto dehydroepiandrosterone is that DHEA is converted to sex hormones. Unlike DHEA, 7-keto isn’t, and this is an important distinction.

Sex hormones include estrogen, testosterone, and progesterone. All three are significant players in your body’s overall health. Like DHEA, levels naturally decline as you age, but hormone therapy boosts levels. 

When you take 7-keto DHEA, you’re not affecting the receptor modulators for hormone production. Instead, 7-keto helps brain function and metabolism. In essence, 7-keto gives you all the benefits of DHEA without having a substantial effect on hormone production. 

7-keto Supplementation

When taking 7-keto DHEA, there are specific mechanisms of action that happen in the body. Mechanism of action describes the effect of a drug or supplement in the body. For example, how a drug targets a cell in terms of function or growth. 

For 7-keto, it has an effect on GABA and PPAR 

GABA and 7-keto

GABA (gamma-aminobutyric acid) is the primary suppressing neurotransmitter in the brain. GABA-like supplements and drugs inhibit spasms and provide a relaxing, soothing feeling in the body similar to alcohol. 

Ethanol or alcohol has been a popular drink for hundreds of years. It brings on different sensations for each person, but generally, it relaxes and reduces anxiety. However, alcohol abuse can happen depending on ethanol intake over time. 

It’s thought that alcohol dependence stimulates GABA pathways and lowers their abilities. One effect of 7-keto is that it modulates ethanol intake. Taking drugs that modulate ethanol help those dependent on it.



Another theory is that DHEA and 7-keto turn on the proliferator-activated receptor alpha (PPAR). Once activated, PPAR-alpha helps boost weight loss, get rid of fat, and build peroxisomes. 

Most of the effects of DHEA in this area have been conducted on mice, but in the future healthy male volunteers may be used.  

Other Health Benefits of 7-Keto DHEA

7-keto has a positive effect on adrenal fatigue and adrenal insufficiency, but it also may provide health solutions, including:

  • Helps Boost Metabolism
  • Improves Cognitive Function:
  • Encourages Balanced Mood
  • Jumpstarts Sex Drive
  • Gives Muscles a Boost
  • Boosts energy levels

How much to take?

7keto DHEA supplements come in different forms and strengths, and the 7-keto cream has 50 of 7-keto per pump. This is a maximum strength dose. Your dosage will depend on your body mass and health condition. 

Men and women taking 7-keto can experience the benefits right away, or it may take up to eight weeks for the entire effect to work. It’s essential to follow the instructions for the supplement to avoid any adverse effects.  


Transdermal Supplementation

Most people assume a pill or tablet is the way to take any kind of supplement, including 7-keto. But the most effective way is with a 7-keto nutritional supplement applied to the skin. It will help treat, cure, or prevent health conditions associated with low DHEA. 

7-keto DHEA can help with many health conditions, including adrenal fatigue. If you suspect you have adrenal fatigue, make an appointment with your doctor to get advice, diagnosis, or treatment. Taking charge of your health begins with that first step.