Can Transdermal Pregnenolone Oil Give You Energy? Unveiling the Benefits and More

March 06, 2024

Can Transdermal Pregnenolone Oil Give You Energy? Unveiling the Benefits and More

Pregnenolone, a naturally occurring steroid hormone, has been gaining attention for its potential health benefits. From memory enhancement to stress reduction, this multifaceted compound has piqued the interest of researchers and health. In this blog, we’ll explore the science behind pregnenolone, its effects on various aspects of well-being, and whether it lives up to the hype.

What Is Pregnenolone?

Pregnenolone serves as a crucial precursor hormone, playing a key role in the production of other essential steroids, including progesterone, DHEA, and estrogen. Naturally synthesized from cholesterol in the brain, adrenal glands, and gonads, pregnenolone acts as a building block for various bodily functions.

Health Benefits of Pregnenolone

1. Cognitive Enhancement: Memory and Learning

Research suggests that pregnenolone may promote memory and learning. By protecting against inflammation in the nervous system, it contributes to cognitive function. Studies have found that patients with Alzheimer’s disease often exhibit significantly lower pregnenolone levels, correlating with disease severity.

2. Mood Regulation: Reducing Depression Symptoms

Pregnenolone directly affects MT-associated proteins (MAPs), which play a role in mood regulation. Defects in MAPs are linked to major depressive disorder (MDD). A small-scale study involving patients with bipolar depression showed positive changes in self-reported depressive symptoms after six weeks of pregnenolone supplementation.

3. Schizophrenia Management: Cognitive Improvements

A 2019 review found that pregnenolone augmentation therapy improved cognitive function in individuals with schizophrenia. It also enhanced overall functioning. Early research suggests that pregnenolone may benefit those experiencing their first schizophrenic episode.

4. Cravings Reduction: Alcohol and Drug Dependence

When individuals with alcohol use disorder (AUD) attempt to quit drinking, cravings can hinder their progress. Pregnenolone supplementation may help reduce these cravings, making the recovery process more manageable.

Safety Considerations and Warnings

While pregnenolone shows promise, it’s essential to exercise caution. Some potential side effects include skin rashes, acne, hair loss, insomnia, and irregular heart rhythm. High levels can lead to aggression, irritability, and unwanted hair growth. Pregnant women should avoid pregnenolone.

Consult Your Healthcare Provider

Before incorporating pregnenolone into your routine, consult your healthcare provider. While research is ongoing, it’s crucial to make informed decisions based on your individual health needs. Remember that dietary supplements are not intended to diagnose, treat, cure, or prevent any disease.


Pregnenolone’s potential benefits extend beyond energy levels. As we continue to unravel its mysteries, always seek professional medical advice and consider the evidence available. Whether you’re exploring pregnenolone for mental clarity, hormonal balance, or overall well-being, consult your healthcare provider to determine if it’s the right fit for you.

Remember, knowledge is power, and informed choices lead to better health outcomes. Stay curious, stay informed, and embrace the journey toward optimal well-being.